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Recent case reports, meta-analyses, and most recently, the breakthrough of 2 novel randomized controlled trials have shown DOACs to be a promising treatment for LV thrombus. Contrarily, some retrospective cohort reviews suggest less .
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In a retrospective analysis of 159 patients with LV thrombus, only 21.5% had a nonischemic cause.17 Mean LVEF was 32%, and the vast majority of LV thrombi occurred in the LV apex. Most patients were treated with OAC, with either a VKA or a DOAC, and 67% were also treated with an antiplatelet agent.
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