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engineering of human CD4- (CD4-LV) and CD8-targeted vectors (CD8-LV) capable to deliver genes selectively into human CD4+ or CD8+ T cells (Zhou et al, 2012, 2015; Bender et al, 2016). Toward in situ generation of CAR T cells, here we report that CD19-reactive CD8+ CAR T cells can be generated in humanized mice upon a
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