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A meta-analysis of these 3 randomized controlled trials, which consisted of a total of 139 patients, found DOACs to be noninferior to VKA with respect to mortality, stroke, or LV thrombus resolution. 93 Pooled analysis also showed that major bleeding was significantly lower with DOACs (2.86% with DOACs versus 13.2% with warfarin; OR, .
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Left ventricular thrombus (LVT) is associated with a significant risk of ischemic stroke (IS) and peripheral embolization. Societal guidelines recommend the use of warfarin, with direct oral anticoagulants (DOACs) only for .
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